![]() It is important that patients receive appropriate pain treatment with careful consideration of the benefits and risks of treatment options. CDC obtained input from experts, stakeholders, the public, peer reviewers, and a federally chartered advisory committee. ![]() CDC developed the guideline using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework, and recommendations are made on the basis of a systematic review of the scientific evidence while considering benefits and harms, values and preferences, and resource allocation. The guideline addresses 1) when to initiate or continue opioids for chronic pain 2) opioid selection, dosage, duration, follow-up, and discontinuation and 3) assessing risk and addressing harms of opioid use. This guideline provides recommendations for primary care clinicians who are prescribing opioids for chronic pain outside of active cancer treatment, palliative care, and end-of-life care.
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